Find The Difference Between Enfamil Newborn And Infant

UPDATE: In the spring of 2017, Enfamil changed the name of their products, Enfamil Newborn formula and Enfamil Infant formula to Enfamil PREMIUM Newborn formula and Enfamil PREMIUM Infant Formula, and the amount of inositol was increased. You can find all the nutrients in the table below.


There are so many baby formula choices on the market that choosing formula to start your baby on can be very overwhelming.

Which formula is best for your baby?

What if your baby doesn’t do well on the formula you choose?

Researching formulas is a great way to increase the chances that you will choose the best formula for your baby on the first try.

The difference between Enfamil Newborn and Infant is small, but knowing the similarities and differences between the formulas will help you make the right choice for your baby.

Enfamil Infant Formula

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Enfamil PREMIUM Non-GMO Infant Formula

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Enfamil Infant was created specifically to meet the needs of babies from birth until one year.

This formula contains nutrients that nourish your baby’s brain, including DHA, choline, and iron.

It also has dual prebiotics, which is designed to provide support to your baby’s growing immune system.

Enfamil Infant is one of the closest formulas to mature breast milk, so it is a great option for moms who are looking for a good supplement to feed their mostly breastfed baby.

Here are the amounts of some of the most important ingredients in Enfamil Infant:

  • Vitamin D- 60 IU for every 100 calories
  • The ratio of whey to casein is 60:40 in Enfamil Infant
  • The protein level is 2 grams per 100 calories.

Parents who feed their babies Enfamil Infant formula generally found that it is easy-to-use and convenient.

They also found that it doesn’t form as many bubbles as most other baby formulas. Their main complaint is that Enfamil is expensive.

Many parents switched their babies from Enfamil Newborn to Enfamil Infant with no issues.


Enfamil Newborn Formula

Enfamil PREMIUM Newborn Infant Formula

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This Formula has the same blend of brain-supporting nutrients as Enfamil Infant.

The main difference between Enfamil Newborn and Infant formula is that Enfamil Newborn was designed to mimic the composition of the mother’s milk during the baby’s first week of life.

It is the Enfamil formula that is designed specifically for babies that are three months old or younger.

Here are the amounts of some key ingredients in Enfamil Newborn:

  • Vitamin D- 75 IU for every 100 calories
  • The ratio of Whey to Casein- 80:20
  • Protein- 2.1 grams in every 100 calories

Parents who use Enfamil Newborn in ready to feed bottles usually appreciate how easy it is to use.

Any nipple can be connected to the bottles, and there is a ml guide on the side of the bottle so that you can easily see how much formula your baby is eating.

Some parents found that Enfamil Newborn caused their baby to be gassy or have diarrhea, likely because it contains a higher amount of lactose than many formulas.

Watch your baby carefully to ensure that they are tolerating the formula well.

What is the Difference Between Enfamil Newborn and Infant?

One Difference between Enfamil Newborn and Infant is the level of vitamin D each one contains.

Since the amount of vitamin D in Enfamil Infant is lower than in Enfamil Newborn, pediatricians often recommend that babies who drink less than one liter of Enfamil Infant formula each day take a vitamin D supplement.

Another difference is that Enfamil Newborn is designed to be used only by very young babies, while Enfamil Infant is formulated for babies from birth to 12 months old.

The table below is showing the similarity and difference between each formula.

Nutrients are per 100 calories (5 fl oz)

Infant Formula Newborn Formula
PROTEIN (g) 2 2.1
FAT (g) 5.3 5.3
CARBOHYDRATE (g) 11.3 11.3
VITAMIN A (IU) 300 300
VITAMIN D (IU) 60 75
VITAMIN K (mcg) 9 9
VITAMIN THIAMIN B1 (mcg) 80 80
VITAMIN B6 (mcg) 60 60
VITAMIN B12 (mcg) 0.3 0.3
NIACIN (mcg) 1000 1000
FOLACIN (mcg) 16 16
PANTOTHENIC ACID (mcg) 500 500
BIOTIN (mcg) 3 3
ASCORBIC ACID (mg) 12 12
CHOLINE (mg) 24 24
INOSITOL (mg) 6 in the old formulation and 24 in the PREMIUM formulation 6 in the old formulation and 24 in the PREMIUM formulation
CALCIUM (mg) 78 78
PHOSPHORUS (mg) 43 43
MAGNESIUM (mg) 8 8
IRON (mg) 1.8 1.8
ZINC (mg) 1 1
MANGANESE (mcg) 15 15
COPPER (mcg) 75 75
IODINE (mcg) 15 15
SELENIUM (mcg) 2.8 2.8
SODIUM (mg) 27 27
POTASSIUM (mg) 108 108
CHLORIDE (mg) 63 63


Be sure to talk to your doctor about the formula that your baby drinks and ask for advice before switching to a new formula, even if you are switching from Newborn to Infant Enfamil.

One of the most important things you can do as a mom is paying close attention to any changes in your baby’s temperament.

It is obvious to parents that they should consider changing the formula their baby is eating if the baby gets diarrhea or cries for hours at a time.

Many babies have reactions to the formula that as noticeable. Your baby’s skin may become red, scaly, or dry.

They may also be more tired than usual, or are spitting up way more than usual. Failure to gain weight is another sign of formula intolerance.

It’s always best to talk to your doctor if you have questions or concerns. After all, nobody knows your baby’s normally better than you do!

Additional information:

Photo credits: Amazon.


  1. My newborn was doing well in the newborn powder formula with the owl on the front of the packaging. After using for two weeks, I went to buy more and then found that it was discontinued. The new newborn premium powder has more inositol in it also. Why was the newborn formula with the owl on the front packaging and the 6 mg of inositol discontinued?

    • Hi Colleen… Enfamil Newborn is being discontinued because of the launch of their PREMIUM products. When they changed the name of Enfamil Newborn powder to Enfamil PREMIUM Newborn powder in the spring of 2017, they changed the formulation. The amount of inositol was increased from 6 milligrams (mg) per 100 Calories [or 5 fluid ounces when it is mixed or used according to label directions] to 24 milligrams per 100 Calories, and they began using non-GMO ingredients. they would expect a child to tolerate Enfamil Newborn powder and Enfamil PREMIUM Newborn powder equally. I hope this information helps!

  2. I have both enfamil newborn formula the one that has the little bird and the one that says premium is it bad for my new born to mix it?

    • Hi Connie
      Well, Enfamil Newborn Formula does have a few differences with Enfamil PREMIUM Newborn Formula, the difference is quantity of inositol in both formulation. So, in my opinion it is not preferable to mix it, however you can use the old formulation first (that has the little bird) until your LO finish this formula and than switch to the new PREMIUM formula

  3. Hey! My partner and I have just arrived in America for the birth of our surrogate babies. We are from Australia so have no clue with US formula brands but Enfamil seems to get good reviews from what we’ve read online. One question I do have is whether the Enfamil Enspire formula would be best from day one or should we use the Premium Newborn for the first 3 months then switch to Enspire? Our babies will be exclusively formula fed. Thanks!

    • Hi Gavin
      Enspire and Enfamil PREMIUM Newborn are iron-fortified infant formulas. Enspire has MFGM and lactoferrin. Enfamil PREMIUM Newborn does not have MFGM or lactoferrin ingredients.
      Enspire has 6 milligrams (mg) of inositol per 100 Calories [or 5 fluid ounces when it is prepared according to label directions], and Enfamil PREMIUM Newborn has 24 milligrams (mg) of inositol per 100 Calories [or 5 fluid ounces when they are mixed or used according to label directions].

      Enspire may be fed from birth. If your baby drinks less than 33.8 fluid ounces (a liter) per day, the doctor may recommend a vitamin D supplement, such as D-Vi-Sol.

      Enfamil PREMIUM Newborn is a routine, milk-based infant formula designed for babies from birth through 3 months of age, to deliver nutrition tailored for newborns.

      In that case, I can’t give a real recommendation. Be sure to ask your babies’ doctor which Enfamil formula best meets their nutritional needs.

      Congrats on the babies!

  4. Just an FYI, these formulas do not have “probiotics” in them. They have prebiotics. This is likely a typo but there is a very big difference between prebiotics and probiotics. You should correct your post.

    Laura Dennis, RD, MAS

  5. I bought Enfamil Premium for Newborn 0-3 months and then I just received Enfamil Infant formula 0-12 months (not premium) as a gift. My question is, Is it okay for my baby to switch from the Premium one to Infant formula after 3 month?

  6. Hi, I just started my baby on newborn formula. I like it alot but it could be causing my baby to be extra gassy due to the high amounts of lactose in it. If that is the case, could I switch my baby to the infant formula now before 3 months of age?

    • Hi Kristin, Enfamil Infant is a routine, milk-based infant formula designed to support your infant’s growth, brain and eye, and immune system development. It’s not suitable for someone with lactose intolerance. Your question has a medical connotation, I suggest you to call Enfamil (at 1-800-222-9123, option 1) if you need to learn more about your baby’s experience with Enfamil Newborn, or email them here: .

  7. My baby will be 3 months old soon and she has been Enfamil newborn since birth. I am thinking to go ahead with switching her to Enfamil infant once newborn runs out which right around the 3 month mark. Is this okay or should I want until she is about to turn 4 months?

  8. what is the difference between regular Enfamil and Enfamil Premium. We have been using the regular Enfamil since birth, but it seems that the Enfamil Premium is easier to find.

  9. Hi,
    My daughter is 2weeks 4 days . I have been breastfeeding her since she was born but my breastmilk is not enough for her so her pediatrician gave me the sample of the enfamil premium for newborn(powdered milk) to try her on but my husband went and bought the enfamil premium infant (the already mixed one). Can I go ahead and start her on that?. I haven’t started her on the one the pediatrician gave yet.

    • Hi Charlotte,
      Enfamil PREMIUM(R) Newborn is intended for babies from birth through 3 months of age. Enfamil PREMIUM(R) Infant is intended for babies from birth through 12 months of age. Enfamil PREMIUM(R) Newborn is similar to Enfamil PREMIUM(R) Infant, with a few exceptions. They are similar but not the same thing and below I will explain why:

      The amount of protein in Enfamil PREMIUM(R) Newborn is 2.1 grams (g) per 100 Calories [or 5 fluid ounces when it is mixed or used according to label
      directions], and Enfamil PREMIUM(R) Infant has 2 grams (g) per 100 Calories [or 5 fluid ounces when it is mixed or used according to label directions].

      Whey to Casein Ratio:
      Enfamil PREMIUM(R) Newborn has the same major ingredients as Enfamil PREMIUM(R) Infant, however, the whey to casein protein ratio is different. There is more of the whey protein concentrate ingredient in Enfamil PREMIUM Newborn than in Enfamil PREMIUM Infant. The whey to casein ratio of Enfamil PREMIUM(R) Newborn is 80:20, and 60:40 in Enfamil PREMIUM(R) Infant. Enfamil PREMIUM(R) Newborn has an 80:20 whey to casein ratio, more like that of breast milk collected during the first week of life, as compared to Enfamil PREMIUM(R) Infant with a 60:40 whey to casein ratio.

      Vitamin D:
      Enfamil PREMIUM(R) Newborn has 75 International Units (IU) of vitamin D per 100 Calories [or 5 fluid ounces when it is mixed or used according to label directions]; and there are 60 International Units (IU) in Enfamil PREMIUM(R) Infant per 100 Calories [or 5 fluid ounces when it is mixed or used according to label directions].

      Enfamil PREMIUM(R) Newborn has 400 International Units (IU) of vitamin D in 27 fluid ounces, closer to the approximate daily intake of babies under three months of age. Enfamil PREMIUM(R) Infant delivers 400 International Units (IU) of vitamin D in a liter (33.8 fluid ounces), closer to the average daily intake of babies four months of age. Vitamin D plays an important role in early bone development.

      Enfamil PREMIUM(R) Newborn has 24 milligrams (mg) of inositol per 100 Calories and Enfamil PREMIUM(R) Infant has 24 milligrams (mg) of
      inositol per 100 Calories.

      So, actually I don’t have all information that I need to give a good/clear advice and that’s why I recommend to you to reach out with Enfamil support, this is the email that you will need: or call them at 1-800-222-9123. But remember that you will need to provide more information about your situation, like:

    • Which Enfamil(R) Formula are you using, including size and form?
    • How long have you used this product?
    • What are the Use by Date and Batch Code (starts with two letters) from the product containers in question?
    • What part of the label is too similar or confusing?
    • Was the wrong product fed to baby? If so, how many feedings did baby receive and how is baby?


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